A Simple Mathematical Model for Wound Closure Evaluation

Alejandra Vidal, MD,^a Hugo Mendieta Zerón, PhD,^b Israel Giacaman,^a María del Socorro Camarillo Romero, PhD,^cSandra Parra López,^b Laura E. Meza Trillo, MD,^d David A. Pérez Pérez,^e Miguel Concha, PhD,^aCésar Torres-Gallegos,^f Sandra L. Orellana, PhD,^f Felipe Oyarzun-Ampuero, PhD,^g and Ignacio Moreno-Villoslada, PhD^g,∗

Abstract

The incidence of ulcers associated to type 2 diabetes mellitus (T2DM) increases every year. We introduce and explore a new mathematical algorithm to evaluate wound-healing in foot ulcers associated to T2DM. Fifteen patients (nine women and six men), mean age of 70 ± 16 years were included. The evolution of their wounds followed-up for a period of 18–45 days. According to the Wagner grading system the ulcers were grade I (5 patients), grade II (9 patients), and grade III (1 patient). Clinically, the type of the ulcers was neuroischemic (12 patients) and neuropathic (3 patients). A new parameter is introduced, the “continuous linear healing rate” Dc that was more accurate with higher values and requires less quantifications than usual formulas to make a wound-healing projection.

For Full Text in the archived Journal of the American College of Clinical Wound Specialists: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5197051/